Job Opportunities

Postdoctoral Fellow-University of Chicago

Postdoctoral Fellow in the Department of Neurology at the University of Chicago.

 

A postdoctoral position is available in the laboratory of Sara szuchet, D. Phil. to study the biology of oligodendrocytes and the molecular mechanism of myelin sheath assembly.
We have recently challenged the 50-year-old dogma that the myelin sheath is no more than a modified version of oligodendrocyte plasma membrane by showing that: i) myelin membranes are synthesized as independent structural entities; ii) are packaged into novel organelles that we have named “myelinophores”; iii) they generate the myelin sheath by stochastic fusion; and iv) the myelin sheath resides within the oligodendrocyte process; i.e., facing the axolemma is the plasma membrane of the oligodendrocyte process. We have also suggested that myelin sheath formation is cell-autonomous. These novel and cardinal concepts call for thinking anew about the basic biology of oligodendrocytes and the factors that are at play in the formation of the myelin sheath and about its pathological destruction. Indeed, the time is ripe for a fundamental change in paradigm on these important problems.

 

Current research aims are to: 1) characterize, biochemically and structurally, the myelinophore organelles with particular emphasis on the manner they deliver their cargo – the myelin membrane tubules; 2) investigate the mechanism of myelin membrane fusion; 3) demonstrate that there is interaction between the axolemma and the oligodendrocyte plasma membrane in the formation of the Nodes of Ranvier and define the nature of this interaction.

 

The successful candidate is expected to hold a Ph.D. degree with a good background in neuroscience, cell biology, biochemistry and structural biology. Hands-on experience with immunological and imaging techniques, electron microscopy and modeling would be an advantage. This position requires an individual with a strong passion for research; someone who is not afraid to face challenges and is willing to contest long-standing believes.

 

The University of Chicago is a private, nondenominational, culturally rich and ethnically diverse coeducational research university located in Hyde Park – a distinct and unique neighborhood in Chicago. The University is well known for its rigorous academic standards. Neuroscience at the University of Chicago covers a wide range of topics from computational to behavioral to molecular. The recently created Grossman Institute of Neuroscience has had a strong impact on fostering the interaction among scientists with diverse interests. In general, because the campus is confined to a relatively small area; it facilitates collaboration with colleagues from different disciplines.
Interested individuals should send a detailed CV with bibliography, a brief statement of research accomplishments and future interests and asked for three letters of recommendation to be sent to szuchet@neurology.bsd.uchicago.edu. The position is available immediately.

 

The University of Chicago is an Affirmative Action / Equal Opportunity / Disabled / Veterans Employer.

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